IP Archives of Cytology and Histopathology Research (ACHR) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination more...
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Volume : 6, Issue : 2, Year : 2021
Article Page : 120-124
Hairy cell leukemia (HCL), a rare, chronic B-cell leukemia, first described as a distinct entity in 1958, was recognized as an entity by the World Health Organization in 2008. The disease accounts for 2% of all leukemias and is more frequent in middle-aged to older men. The diagnosis is based on the hairy lymphoid cells in the peripheral smear and the bone marrow aspiration cytology and the bone marrow biopsy showing a monotonous interstitial infiltrate with a fried egg appearance. The classic immunophenotypic profile in the flow cytometry and the BRAF V600E mutation confirm the diagnosis. Herein we report a 52-
year-old male patient presented with pancytopenia, high-grade fever, and weight loss. The characteristic histomorphological and the flow cytometry features of this leukemia will be used to discuss further the recent updates on the distinct clinicopathologic features, differential diagnosis, treatment, and prognosis of the entity.
Keywords: Hairy cell leukemia, Monotonous, Fried egg, Flow cytometry, Pancytopenia.
How to cite : Kottangal G V, Vidyadharan G , Hairy cell leukemia - A case report with recent updates. IP Arch Cytol Histopathol Res 2021;6(2):120-124
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