IP Archives of Cytology and Histopathology Research

Print ISSN: 2581-5725

Online ISSN: 2456-9267

CODEN : IACHCL

IP Archives of Cytology and Histopathology Research (ACHR) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination more...


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Review Article


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145-152


Authors Details

Felice Faizal*, Umesh Kapoor, Balachandra Nambiar


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A systematic review of autopsy findings in COVID 19: The road ahead


Review Article

Author Details : Felice Faizal*, Umesh Kapoor, Balachandra Nambiar

Volume : 6, Issue : 3, Year : 2021

Article Page : 145-152

https://doi.org/10.18231/j.achr.2021.036



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Abstract

Autopsy data on the COVID 19 is scarce and has left a gap in understanding the disease process. This study attempts to review the available data gleamed from the limited autopsies performed worldwide which would help in guiding future treatment protocols.A literature search was undertaken using PubMed, Scopus, Embase and Google search engines for original and review articles. Studies that mentioned autopsy and COVID-19 were included. Findings from a total of 16 studies mentioning 139 autopsies in confirmed cases of COVID 19 were analysed. The most common features in fatal cases has been cough followed by progressive dyspnoea. Fatal cases show a predominance in the elderly age group, male gender and individuals with blood type A.Autopsy findings in various organs have been described with the prominent feature being Diffuse alveolar damage and microthrombii formation in the lung. Massive pulmonary embolism and Deep vein thrombosis seem to be overlooked features in the fatal cases.Complement mediated destruction is a potential pathogenetic mechanism suggested by C4d and C5b-9 deposition in the skin lesions and lung capillaries.To conclude, Prophylactic dose of low molecular weight heparin, chest CT and serial D-dimer levels are recommended in all patients with suspected COVID 19 admitted to the hospital.The demonstration of complement mediated injury to various tissues also suggest a role of anti-complement therapy to improve patient outcomes.Detailed autopsy studies are required to evaluate the pathology of COVID 19 in various organs to understand the disease process better.
 

Keywords: Autopsy COVID-19, Autopsy SARS-CoV-2, Postmortem findings COVID-19


How to cite : Faizal F, Kapoor U, Nambiar B, A systematic review of autopsy findings in COVID 19: The road ahead. IP Arch Cytol Histopathol Res 2021;6(3):145-152

Copyright © 2021 by author(s) and IP Arch Cytol Histopathol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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