IP Archives of Cytology and Histopathology Research

Print ISSN: 2581-5725

Online ISSN: 2456-9267

CODEN : IACHCL

IP Archives of Cytology and Histopathology Research (ACHR) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better more...


Article type

Case Report


Article page

283-287


Authors Details

Jaydeep N Pol*, Neha M Bhosale, Girish A Kadkol, Madhura D Phadke, Swpana S Magdum


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FNAC Diagnosis of eosinophilic variant of chromophobe renal cell carcinoma – A challenge for cytopathologists


Case Report

Author Details : Jaydeep N Pol*, Neha M Bhosale, Girish A Kadkol, Madhura D Phadke, Swpana S Magdum

Volume : 6, Issue : 4, Year : 2021

Article Page : 283-287

https://doi.org/10.18231/j.achr.2021.061



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Abstract

Chromophobe Renal Cell Carcinoma (ChRCC) is a rare distinct subtype of Renal cell carcinoma. It arises from intercalated cells of the renal cortex. The cytomorphological features of ChRCC show significant overlap with Clear cell Renal Cell Carcinoma (CCRCC) and Oncocytoma. The prognosis of ChRCC is intermediate between benign Renal Oncocytoma and the relatively aggressive CCRCC. Hence, a correct pre or intra-operative cytodiagnosis helps in deciding the extent of surgery. We report a case of eosinophilic variant of ChRCC in a 70 years female, diagnosed on Fine Needle Aspiration Cytology (FNAC).The Immunocytochemistry (ICC), histology and Immunohistochemistry confirmed the diagnosis of ChRCC. Diagnosing ChRCC; especially its eosinophilic variant on FNAC is very challenging. Prominent cellular heterogeneity, pleomorphism, perinuclear halos and binucleation are important diagnostic clues for cytodiagnosis of ChRCC. In difficult cases, ICC helps in confirming the diagnosis.
 

Keywords: Chromophobe, Renal Cell Carcinoma, Eosinophilic variant, FNAC


How to cite : Pol J N, Bhosale N M, Kadkol G A, Phadke M D, Magdum S S, FNAC Diagnosis of eosinophilic variant of chromophobe renal cell carcinoma – A challenge for cytopathologists. IP Arch Cytol Histopathol Res 2021;6(4):283-287

Copyright © 2021 by author(s) and IP Arch Cytol Histopathol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.org)







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