IP Archives of Cytology and Histopathology Research

Print ISSN: 2581-5725

Online ISSN: 2456-9267

CODEN : IACHCL

IP Archives of Cytology and Histopathology Research (ACHR) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing the article more...

Article type

Case Report


Article page

247-250


Authors Details

Arijita Banik*, Soumya B.M, Seema Bijjaragi, Vardendra Kulkarni, Chandrasekhar H.R


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Sporadic diffuse gastric ganglioneuromatosis causing gastric outlet obstruction in an adult patient: A rare case report and literature review


Case Report

Author Details : Arijita Banik*, Soumya B.M, Seema Bijjaragi, Vardendra Kulkarni, Chandrasekhar H.R

Volume : 7, Issue : 4, Year : 2022

Article Page : 247-250

https://doi.org/10.18231/j.achr.2022.056



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Abstract

Objective: Gastrointestinal ganglioneuromatosis is a rare benign neural neoplasm, consists of hyperplasia of nerve fibers, ganglion cells, and schwann cells in the wall of stomach and intestine. The disease may affect any part of the gastrointestinal tract but involvement of stomach is extremely unusual. Mainly are of three types: polypoid ganglioneuromas, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. To our knowledge, only two cases were reported as diffuse ganglioneuromatosis located in the stomach.
Case Report : 27-years male patient, admitted with complaint of dysphagia for both solid and liquid and recurrent non-bilious vomiting since 1 week underwent Billroth - 1 procedure and antral segment of stomach was sent for histopathological examination. A histopathological diagnosis of Diffuse Gastric Ganglioneuromatosis with muscular mural hypertrophy was made. The presence of ganglion cells and positive staining for S-100 and NSE confirms the diagnosis.
Conclusion: Obstructive gastrointestinal symptoms with a possibility of diffuse ganglioneuromatosis is mainly a disease of young children and infant. But an adult patient, which is an unusual age group, presenting with obstructive gastrointestinal symptoms, the rare possibility of Diffuse ganglioneuromatosis and intestinal neuronal dysplasia should be considered and investigated in order to avoid unnecessary and extensive surgical intervention.
 

Keywords: Ganglioneuromatosis, Ganglion cells, S100, NSE


How to cite : Banik A, B.m S , Bijjaragi S, Kulkarni V, H.r C , Sporadic diffuse gastric ganglioneuromatosis causing gastric outlet obstruction in an adult patient: A rare case report and literature review. IP Arch Cytol Histopathol Res 2022;7(4):247-250

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