IP Archives of Cytology and Histopathology Research

Print ISSN: 2581-5725

Online ISSN: 2456-9267

CODEN : IACHCL

IP Archives of Cytology and Histopathology Research (ACHR) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing the article more...

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Original Article


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4-13


Authors Details

Lakshmikanth Ramiah Madanagopaal, Priya Subashchandrabose, Shanthakumari Sivanandam


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Analysis of PAX5 expression of Hodgkin’s and non-Hodgkin’s lymphomas: in comparison with routine panel


Original Article

Author Details : Lakshmikanth Ramiah Madanagopaal, Priya Subashchandrabose, Shanthakumari Sivanandam

Volume : 1, Issue : 1, Year : 2016

Article Page : 4-13


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Abstract

Aim of the study: To assess the expression of PAX5 in different types and stages of lymphomas and to study its utility in comparison with the classical pan B and T cell markers.
Materials and Methods: Immunohistochemistry was done to detect the expression of PAX5, CD45, CD3, CD20, CD15 and CD30 in all cases of lymphoma reported for a period of two years.
Results: 59 cases were reported as malignant lymphomas giving an overall incidence of 6.3% in our hospital. The age group ranged from 3 years to 75 years with a male preponderance. Nineteen cases were excluded owing to inadequate tissue samples. Of the 40 cases, 28 were nodal and 12 extra-nodal lymphomas. 33 cases were non-Hodgkin’s lymphoma and 7 were Hodgkin’s lymphoma. 23 out of the 40 cases were positive for PAX5 and out of 21 cases of B cell non-Hodgkin’s lymphoma, 18 were positive. Reed-Sternberg cells of Hodgkin’s lymphoma were positive in 5 cases. PAX5 was positive in most of the B cell non-Hodgkin’s lymphoma and Hodgkin’s lymphoma regardless of the stage, age, sex and site. PAX5 was negative in all T cell non-Hodgkin’s lymphoma and the cases of unclassified category.
Conclusions: This study suggests that B cell neoplasms and Reed Stenberg cells strongly expressed PAX5 in comparison to classical lymphoma panel and hence can be a useful marker. However a larger prospective study on PAX 5 expression in Hodgkin’s Lymphoma is vital to look for an increased expression in subset of Indian population.

Keywords: B-cell Lymphoma, Hodgkin’s lymphoma, Immunohistochemistry, PAX5, T-cell Lymphoma

 


How to cite : Madanagopaal L R, Subashchandrabose P, Sivanandam S, Analysis of PAX5 expression of Hodgkin’s and non-Hodgkin’s lymphomas: in comparison with routine panel. IP Arch Cytol Histopathol Res 2016;1(1):4-13

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